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Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation

(PubMed) Song K, Milner JA

Patients included in the trial had HbA 1c 7 to 10% and were treated with either: diet and exercise alone or 1 to 3 oral antidiabetic drugs (metformin, sulfonylurea, glitazone or sodium-glucose co-transporter 2 inhibitor)

They can provide guidance on the appropriate dosage, formulation, and any potential interactions with medications

Intestinal and hepatic biochemical analysis (iFABP, AST, ALT) Plasma levels of aspartate aminotransferase (Abcam, Cambridge, MA) and alanine aminotransferase (Cloud-Clone, Katy, TX) were determined with commercial kits

Monitoring of vital parameters